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Best Supplements for Arthritis Pain

Updated April 2022
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Best of the Best
Osteo Bi-Flex Triple Strength with Vitamin D
Osteo Bi-Flex
Triple Strength with Vitamin D
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Triple Strength
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Supplement that includes vitamin D to assist with joint pain and inflammation.


These triple-strength tablets include glucosamine HCl, chondroitin, and vitamin D to help immune and joint health. Several users reported pain relief in less than 1 week. Only requires 2 capsules per day.


Those with allergies should know ingredients contain shellfish. A few users reported the pills being difficult to swallow due to size.

Best Bang for the Buck
Doctor's Best Glucosamine Chondroitin MSM with OptiMSM
Doctor's Best
Glucosamine Chondroitin MSM with OptiMSM
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A potent combination of 3 ingredients to help build the cushy cartilage that serves as a shock absorber for your joints.


Each serving provides 750 milligrams of glucosamine sulfate, 600 milligrams of chondroitin sulfate, and 500 milligrams of MSM. Many users reported also giving it to their dogs with significant improvements. Non-GMO.


Fairly large capsules to swallow; some reported difficulty taking them.

Garden of Life Joint Supplement for Men and Women
Garden of Life
Joint Supplement for Men and Women
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Plant-Based Ingredients
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A blend of enzymes and antioxidants that work to improve overall joint health and contribute to greater mobility.


Comes in a container of 400 tablets. Has enteric coating for better absorption, and is soy-free. Supplements are used to increase range of motion related to joints. Can be used after active movement for a quicker recovery time.


Appeared to cause stomach issues in a few customers.

BioSchwartz Turmeric Curcumin with BioPerine
Turmeric Curcumin with BioPerine
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Customer Favorite
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This non-GMO option relies on the anti-inflammatory benefits of turmeric to support joint health and improve mobility.


Comes with 90 capsules. Ingredients include high-potency turmeric and bioperine. Designed to support absorption and bioavailability. Made without fillers, binders, and preservatives, as well as being free of common allergens such as wheat, eggs, and soy. Can also contribute to overall immune system health.


Some buyers believe these are not worth the price.

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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
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We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

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Buying guide for Best supplements for arthritis pain

Arthritis pain sufferers often seek relief through prescription or over-the-counter analgesics, steroids, anti-inflammatory drugs, and heat therapy. While these treatments may be effective in the short term, they can be expensive over time. Some treatments, such as cortisone injections, can actually accelerate tissue deterioration. A popular homeopathic alternative is the arthritis pain supplement. These supplements often include sugar-derived ingredients such as glucosamine and/or chondroitin as well as a sulfur-based product called MSM (methylsulfonylmethane).

Because supplements targeted at arthritis pain are considered food products and not medication, there are no FDA standards. Some contain therapeutic levels of vitamins or minerals; others rely heavily on unregulated ingredients like glucosamine and chondroitin. We offer an in-depth discussion of the benefits and potential drawbacks of arthritis pain supplements in this detailed guide.

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The FDA considers glucosamine chondroitin MSM supplements to be food products, not drugs. Manufacturers are not required to verify any health claims or benefits.

How do arthritis pain supplements work?

The basic mechanism behind arthritis pain supplements is tissue repair. Osteoarthritis and other medical conditions cause painful inflammation and degenerative tissue damage primarily in the joints. As the body loses its natural lubricants and protective cartilage, the nerves, muscle tissue, and bones can become inflamed and painful to the touch. Prescription pain medications usually address inflammation and swelling, but they do not always address the loss of fluids, cartilage, and bone tissue over time.

This is where arthritis pain supplements enter the picture. Natural ingredients ordinarily produced in the human body, such as glucosamine and chondroitin, are supposed to encourage the regrowth of cartilage and other protective tissues. MSM is a sulfur-based substance that penetrates inflamed tissue and helps ease inflammation. Other ingredients found in these supplements may also help improve overall bone density, restore lubricating synovial fluids, or reduce inflammation.

Are arthritis pain supplements safe and effective?

In terms of consumer safety, most arthritis pain supplements do not contain controlled substances or other prescription-strength medications. They are classified as food supplements, not medication. However, you should consult with your physicians before beginning a regimen of this type. Diabetics should be careful when using sugar-based ingredients such as glucosamine and chondroitin, and those with severe shellfish allergies should also use caution.

The effectiveness of arthritis pain supplements is a matter of debate. The beneficial effects may not appear for several months, as the body slowly begins to rebuild lost tissue or fluids. Anecdotal testimony from satisfied users indicates a noticeable degree of relief from pain and swelling, but these claims are not fully supported by scientific studies.

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Expert Tip
Some manufacturers add other natural anti-inflammatory ingredients, such as shark fin cartilage and turmeric, to their glucosamine chondroitin blends.

Common ingredients in arthritis pain supplements

The default ingredient list of many arthritis pain supplements includes glucosamine, chondroitin, and MSM. However, manufacturers are not restricted to these ingredients. Here is a list of potential ingredients which should be clearly displayed on product packaging.


Glucosamine is a natural substance produced by the human body. It is usually found in joint fluids, bone marrow, and shellfish. It helps with the repair of cartilage damaged by inflammation. It can raise blood sugar levels in diabetics but is generally considered safe. There is no established therapeutic dose.


Chondroitin is similar on a molecular level to glucosamine and is also found naturally in human joint tissue. Several reputable studies link the use of chondroitin with significant relief from osteoarthritis pain. It has some blood-thinning properties, so users taking blood-thinning medications or certain cancer drugs should caution.


MSM is naturally found in green plants, but it is also produced in the human body. It is often touted as a miracle supplement that can help with a wide variety of medical conditions. The primary function of MSM in arthritis pain supplements is to deliver beneficial sulfur to damaged tissues.


Turmeric is a spice with a number of claimed health benefits. It is commonly found in prepared mustards and Indian food. As a supplement, turmeric is considered to have anti-inflammatory properties.

Vitamin D3

Some arthritis pain supplement blends include standardized vitamins and minerals, including vitamin D3, which helps strengthen bone tissue and improve general resistance to inflammation.


Calcium is an important supplement in terms of overall bone health. It is not always included in arthritis pain supplements, but users will benefit from its presence. The dosage may not be therapeutic, however, so additional calcium supplements may be helpful.

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Did you know?
Glucosamine chondroitin supplements are used to relieve symptoms of osteoporosis, cataracts, glaucoma, bladder problems, heart disease, high cholesterol, and TMJ

Arthritis pain supplement prices

Blends containing glucosamine, chondroitin, and/or MSM are among the pricier supplements on store shelves. There are several reasons for this, including high consumer demand and a challenging manufacturing process. However, prices vary between well-known and lesser-known brands. Beware of imported products sold in bulk at deep discounts. Here’s a general idea of what to expect.

Under $15

At this price range, many supplements contain minimal amounts of glucosamine, chondroitin, or MSM. The rest of the ingredients are generally a blend of natural and artificial vitamins, fatty acids, and gelatin. Effectiveness varies, and the product may only be available in pill or capsule form.

Between $15 and $25

This price range includes many of the commercial brands sold in the dietary supplement aisle. The ingredient list typically touts a blend of glucosamine, chondroitin, and MSM, along with other anti-inflammatory ingredients such as turmeric, shark fin cartilage, and hyaluronic acid. The supplements may be in pill, capsule, or powder form.

Over $25

High-end arthritis pain supplements are generally sold online and in specialized health food stores. Most include therapeutic levels of glucosamine, chondroitin, and MSM, along with an array of vitamins and minerals. Calcium, vitamin D3, and hyaluronic acid are common ingredients. This is also the price range where flavorless powders are sold in bulk.

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Did you know?
Glucosamine naturally occurs in bone marrow, bone tissues, fungi, and shellfish.


Adding an arthritis pain supplement to your daily regimen may help slow the degeneration of joint tissue, but you should not expect immediate or dramatic results. Here are some tips to keep in mind.

  • Allow several months of regular use before evaluating effectiveness. Rebuilding lost collagen and cartilage takes time, and natural supplements work at a slower rate than prescription anti-inflammatory drugs.

  • Consult with a physician before, during, and after taking a supplement. Your doctor will want to make sure there are no dangerous interactions with prescription medications and no serious side effects associated with the ingredients in your supplement.

  • Shop according to brand and reputation, not price. Because this type of supplement is not regulated, few industry standards exist. To find the best and safest products, avoid ordering products from unfamiliar suppliers.

  • Read the list of ingredients carefully. The ingredients in your supplement may go beyond the basic glucosamine/chondroitin combination. Products containing sulfur, for example, may be good for rebuilding cartilage, but they may also trigger allergic reactions. Shellfish derivatives are common ingredients, too — if you have an allergy to shellfish, you should not take these supplements.

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Glucosamine and chondroitin are formed from sugar molecule chains, but the main component of MSM is sulfur.


Q. I have type 2 diabetes. Can I safely add glucosamine chondroitin supplements to my diet to help with joint pain?

A.Both glucosamine and chondroitin are derived from sugar chains, which means they can raise blood glucose levels. Consult with a physician before using these supplements, as the risks may outweigh the benefits.

Q. I’ve heard stories about supplements with glucosamine, chondroitin, and MSM actually making arthritic joint pain worse for some users. Is this true, and what might cause these problems?

A.There is minimal scientific research on the benefits and risks of glucosamine chondroitin supplements. One study was halted because recipients of the supplement reported increased pain compared to placebo recipients. Some users may be allergic to shellfish, a key source of glucosamine. Others may not have stopped taking the supplements before realizing any long-term benefits.

Q. My doctor advised me not to take glucosamine chondroitin supplements for my osteoarthritis pain because of interactions with my other medications. Is this a common concern?

A. Chondroitin has a natural blood-thinning element, which means it could interact with prescription blood thinners such as Warfarin or Coumadin. These supplements can also interact with certain cancer drugs. It is always a good idea to consult a medical professional before adding a supplement to your diet.