Best Hypoallergenic Mattress Covers

Updated November 2021
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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. Read more  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.Read more 
Bottom line
Best of the Best
SafeRest Premium Hypoallergenic Waterproof Mattress Protector
Premium Hypoallergenic Waterproof Mattress Protector
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Gentle yet Waterproof
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This ridiculously popular mattress protector is a must-have for health conscious consumers and those suffering from severe allergies.


Completely waterproof, protecting against spills and urine. Designed as a fitted sheet to easily take on and off. Customers appreciate the silence of the fabric.


Not the most breathable fabric. Does not zip around the entire mattress.

Best Bang for the Buck
Linenspa Zippered Encasement
Zippered Encasement
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Sealed and Vinyl-free
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A mattress encasement offering full, 6-sided coverage for those wanting supreme allergen protection.


Free of vinyl, making the product safe for children. Zippered closure for full coverage. Noiseless fabric. Customers appreciate the product's lightweight, cool feel.


Some buyers wish the material was thicker. Fabric could be softer.

SureGuard Mattress Protectors Premium Fitted Cotton Terry Cover
SureGuard Mattress Protectors
Premium Fitted Cotton Terry Cover
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Quiet Cotton Terry
Bottom Line

Customers needing a specifically cotton terry cover will find their match in this high quality option.


Protects against dust mites and other allergens. Breathable fabric keeps cool throughout the night. Cotton surface is completely noiseless. Simple to put on and take off.


Tends to shrink after being washed. Some customers complain that the cover is not completely waterproof.

Hanna Kay Hypoallergenic Quilted Stretch-to-Fit Mattress Pad
Hanna Kay
Hypoallergenic Quilted Stretch-to-Fit Mattress Pad
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Perfect Fit
Bottom Line

Primarily intended for protection, this pad doesn't offer significant support, but it fits most mattresses like a glove.


Boasts 40% more filling than competitors. Breathable cotton and poly blend are hypoallergenic. Diamond stitching helps prevent bunching. Fits mattresses up to 16-inches deep, twin or queen.


It isn't very supportive, and it has a tendency to pill.

Luna Mattress Protectors Premium Hypoallergenic Waterproof Mattress Protector
Luna Mattress Protectors
Premium Hypoallergenic Waterproof Mattress Protector
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Cotton with Airflow
Bottom Line

One of the highest-selling mattress covers recognized for its impressive airflow technology.


Made with high-quality cotton. Customers rave over the completely waterproof design. Airflow technology allows for a breathable protector with a helpful cooling system.


A few customers wish the material was softer. Side covers are somewhat loose.


We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

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Buying guide for best hypoallergenic mattress covers

Do you constantly wake up congested and wheezing with a stuffy nose? Does a night in bed seem to bring on watery, itchy eyes or irritated skin? If so, you may be able to thank the resident dust mites and other allergens that keep you company while you sleep. Try reducing those overnight guests and protect your pricey bed from annoying microscopic bugs by covering it with a hypoallergenic mattress cover.

A hypoallergenic mattress cover may be made from tightly woven cotton, a cotton blend, bamboo fabric, or a non-porous material like vinyl or soft plastic. It’ll keep unsavory spills from leaking into your mattress, and it’ll also serve as a barrier to prevent common household allergens (like dust mites) from entering your mattress.

Health studies suggest that a hypoallergenic mattress cover should be part of your overall plan to reduce allergens in your home. To select the right mattress cover, look for one that you’ll be able to take on and off easily so it can be regularly cleaned. We’ll share other tips on using hypoallergenic mattress covers in this article so you can relax at night and enjoy your dreams.

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Do you have a hypoallergenic mattress cover that makes you too warm when you sleep? Invest in some cotton percale sheets with about 300 thread count. These sheets can help keep you cool.

Key questions

Which hypoallergenic mattress cover is right for you? That depends on several factors. Answering these two questions will help you hone in on the features you’ll want to consider.

Is the cover for a child’s mattress?

If you’re buying a hypoallergenic mattress cover for a child who may wet the bed, you’ll want to protect the mattress further. Hypoallergenic mattress covers aren’t waterproof. Consider placing disposable or washable waterproof bed pads, also called overlays, either underneath or on top of the hypoallergenic mattress cover. For babies, you’ll find waterproof hypoallergenic crib mattress protectors that are fully encased.

If the cover is for your mattress, do you typically become hot and sweaty while sleeping?

Sleeping with any type of material underneath your sheets may make you feel warm at night. If this sounds like you, consider a breathable mattress cover. A breathable mattress cover is made from cotton, a cotton blend, or possibly cotton terry with a membrane back coating that’s semi-breathable.

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Did you know?
Dust mites love to eat your dead skin cells, which is why your bed is a hot spot for them. Every night, we shed thousands of dead skin cells right onto our sheets, pillows, and mattress.

Key considerations

Membrane vs. non-membrane cover

There are two categories of hypoallergenic mattress covers: membrane (laminated) and non-membrane (non-laminated, also known as fabric). Laminated covers are typically the less costly of the two. There are pros and cons to both types.

Membrane: Urethane membranes are considered full barriers, and they’re highly resistant to water. Fully encased membrane (laminated) covers offer protection from both dust mites and bed bugs, but they may crinkle and be less breathable, which can cause your body heat to rise when you sleep. Many of these covers are advertised to be vinyl free.

Non-membrane: Tightly woven cotton, terry cotton, bamboo, polyester, and blend fabrics are lightweight, breathable, cool, soft, and generally more comfortable to sleep on. However, they aren’t considered to be full barriers. Their pore sizes may not fully protect against bed bugs or moisture.

Fully encased vs. partially encased fitted cover

There are pros and cons to having a fully encased or partially encased fitted cover. A fully encased cover offers total protection for your mattress, but even with a zipper, it can be tough to get it on and off the mattress when you need to throw it in the washer. However, if you’re up for the exercise, putting a fully encased cover on any mattress will give you a workout. A fitted cover with partial coverage offers limited protection from dust mites, but it is as easy to take on and off as a fitted sheet.


Noise-free: A mattress cover with a cotton surface will be silent when you’re sleeping on it. In other words, it won’t crinkle or make sounds when you turn over in bed.

Zippered closure: A zippered encasement fully covers your mattress. Look for a six-sided product rather than a five-sided one. These covers typically fit 12-inch-deep mattresses and pillow tops. The zippers tend to be durable because manufacturers understand that you need to manhandle your mattress to get the cover on and zipped up.

Cooling: A breathable cotton terry or bamboo fabric hypoallergenic mattress cover will wick moisture from your body and help keep you cool while you sleep. Non-breathable covers aren’t as cooling as breathable products.


Vacuum with HEPA filter: Dyson Ball Multi Floor 2 Upright Vacuum Cleaner
A vacuum with a HEPA filter can capture microscopic dust mites from all surfaces in your home. Even better is a certified asthma- and allergy-friendly vacuum with a whole-machine HEPA filtration system that makes sure the allergens that are trapped inside the vacuum aren’t expelled back into the air. Dyson makes fantastic vacuum cleaners, and we strongly endorse this one.

Hypoallergenic pillow cover: Alaska Bear Natural Silk Pillowcase
A pillow cover can prevent dust mites from taking up residence in your pillows. Even better are hypoallergenic pillowcases like this one from Alaska Bear that are silky and soft to sleep on.

Hypoallergenic box spring encasement: Hospitology Products Sleep Defense System Zippered Box Spring Encasement
Investing in a zippered box spring cover completely protects the bottom of your bed from dust mites and bed bugs. It’s an added piece of insurance to keep your sleeping space allergen free. This affordable cover from Hospitology Products is available in bed sizes from twin to California King.

Disinfectant spray for linens: Lysol Disinfectant Spray, Crisp Linen
Between washings of your mattress cover, lightly spray the surface of your bed with a disinfectant before putting washed bedding back on. The spray adds to your protection by killing cold and flu viruses as well as odor-causing bacteria. It also adds a fresh fragrance to your bedding.

Hypoallergenic mattress cover prices

Inexpensive: Between $7 and $14, you’ll find basic hypoallergenic covers for twin to queen mattresses that attach via drawstring or straps. You’ll also find a few zippered covers for twin beds and waterproof hypoallergenic fitted crib and toddler bed covers. Even at this low price, you’ll find both laminated and breathable covers.

Mid-range: Between $15 and $27, you’ll find better fitted and fully encased hypoallergenic mattress pads that cover 18-inch-deep mattresses of all sizes. Many covers in this range are made of cotton terry or bamboo fabric with a membrane backing.

Expensive: From $27 to $50, you’ll find more fully encased, zippered covers for larger beds. Many will fit beds with 21-inch-deep mattresses. Some will have longer warranties, such as a 15-year warranty. A few premium hypoallergenic covers are made from Turkish cotton or organic cotton. Many are also made from bamboo fabric.


It’s a good idea to get a hypoallergenic mattress cover even if you’re not allergic to dust mites. Along with your dead skin cells, live and dead dust mites — and their droppings — can add several pounds to an uncovered mattress over the years. It’s not the stuff of nightmares; there are studies to back up the science.

Take it with a grain of salt when a manufacturer of a latex, foam, or wool mattresses suggests that you don’t need a dust mite mattress cover. Though the lanolin in wool mattresses may repel dust mites, wool will still capture allergens that fall onto an exposed surface. And though latex and memory foam are dense materials, dust mites still love them. As a safety measure to protect you from allergens, cover all mattresses with a hypoallergenic mattress cover.

Some allergens are small enough to migrate through the teeth of a zipper. If you have a fully encased and zippered cover, do the following. Place the zipper at the foot of the bed. Use zipper adhesive tape or common blue painter’s tape to further cover the zipper teeth. This creates an added barrier that can be easily removed.

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You may see “HNN cooling technology” on the labels of hypoallergenic covers. That simply means the fabric picks up moisture from your body and wicks the heat away to quickly evaporate, keeping your body cooler.


Q. What does “pore size” refer to in a hypoallergenic mattress cover?
This is the space between the fibers. The more tightly the fabric is woven, the smaller the pore size. Note that as pore size decreases, so does airflow.

Constricted pores can help prevent dust mites, dust mite fecal matter, and mite body parts from squeezing through the cover and into your mattress. Though we don’t breathe in whole dust mites, we do inhale their fecal matter and parts while sleeping. Dust mite particles can come as large as 10 microns. To give you a basis of comparison, mold spores are an average of 3 microns.

If you want a cover to be effective against dust mites, look for one with a pore size of 10 microns or less — or 3 microns or less to protect you from just about everything else.

Q. How should I clean a hypoallergenic mattress cover?
Generally speaking, you should vacuum your hypoallergenic mattress cover every couple of weeks and launder it one to three times a year (or more). Wash the cover in hot water and tumble it dry on low heat. Keep in mind, however, that the product label may trump these instructions.

Q. What else should I do to reduce allergens in my house in addition to using a hypoallergenic mattress cover?
You should regularly wash your bed sheets in hot water and dry on hot heat in the dryer to kill new dust mites. In addition, vacuum your furniture and drapes with a HEPA filter. HEPA (high-efficiency particulate air) filters trap extremely tiny airborne particles that regular filters can’t always capture. In addition, instead of opening your windows to let in dust and pollen, use an air conditioner — and remember to frequently change the filters.

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