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Best Pet Stain and Odor Removers

Updated April 2024
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Best of the Best
Rocco & Roxie Supply Co. Professional Strength Stain & Odor Eliminator
Rocco & Roxie Supply Co.
Professional Strength Stain & Odor Eliminator
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Premium Brand
Bottom Line

Our cleaning expert likes that this product is safe around pets and children, and it gets rid of all odors and stains, including pet-related ones.


A versatile formula in a spray bottle that can be used on any stain or surface. Can be used as a laundry stain treatment. Users praise its effectiveness at preventing animals from returning to the same spot. Safe enzymatic formula. Money-back guarantee.


Repeat use may be necessary on serious stains. Mixed reviews on the scent, but most users find it pleasant.

Best Bang for the Buck
Nature's Miracle Stain and Odor Remover w/Odor Control
Nature's Miracle
Stain and Odor Remover w/Odor Control
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Customer Favorite
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Many dedicated customers praise this product for living up to its promise of effectively removing most stains and odors.


This product has become a trusted product among pet owners for its reliability at removing all types of animal stains and odors with natural enzymes. Safe for most surfaces. Effective formula.


Some tough urine odors may require several applications to thoroughly remove, but most are eventually eliminated.

Sunny & Honey Pet Stain & Odor Miracle
Sunny & Honey
Pet Stain & Odor Miracle
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Strong Scent
Bottom Line

This enzyme cleaner earns our expert's praise for making most stains and odors disappear completely.


Formulated to be safe and effective on all types of pet stains and odors. Effective formula. Spray bottle. Not tested on animals. A percentage of sales goes to help animal causes. Comes with a money-back guarantee.


You might have to apply this several times on stubborn odors like cat urine. Scent may be a bit strong for some users.

Bissell Woolite Advanced Pet Stain and Odor Remover
Woolite Advanced Pet Stain and Odor Remover
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Trusted Brand
Bottom Line

A two-pack from a trusted brand that our expert notes kills stains and odors as well as sanitizes.


A pleasantly scented enzymatic cleaner. Kills bacteria and germs. Two bottles are included for the price. Spray bottles have two settings for customized cleaning.


Will not remove food stains.

Bubba's Rowdy Friends Pet Supply Company Pet Stain & Odor Terminator
Bubba's Rowdy Friends Pet Supply Company
Pet Stain & Odor Terminator
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Natural and Gentle
Bottom Line

A solid option that our expert recommends for those who are house-training new pets.


Enzyme-powered cleaner in a 1-gallon jug. Formulated with natural ingredients; works on most stains and surfaces. Can also be used as a stain treatment for some garments. Money-back guarantee.


Inconsistent results with tough odors. Mixed opinions on the scent – some say it's pleasant; others say it's too strong.

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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews 

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

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Buying guide for Best pet stain and odor removers

Messes go with the territory -- when you have pets, you’re going to clean up after them. As much as we love our fur babies, they do sometimes make messes, and having a good pet stain and odor remover on hand is a must.

Most of these products use specially formulated enzymes to break down organic matter – feces, urine, vomit, and even drool – to eliminate the stain and its odor. Others use a more traditional, detergent-based approach to clean up pet messes. With so many pet stain and odor removers on the market, you might be overwhelmed by the choices. How do you decide which formula is best for your household?

Take into account the kind of pet you need to clean up after and the types of surfaces you need to clean. Let us guide you through these key details so you can find the right stain and odor remover for you.

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Activate the enzymes by shaking bottles of enzymatic pet stain and odor remover before use.

Key considerations

Accidents happen

Pet accidents can happen for a number of reasons: your pet doesn’t have access to the outdoors or the litter box, your dog or cat gets sick, or your puppy is in the process of being toilet trained. This means your house is fair game for their bodily functions, and the result can be a mess on the carpet, hardwood floor, clothing, furniture, or pet bed. Many times we can’t catch pet messes right when they happen, and they seep into the carpet, upholstery, or floor. The key is finding a pet stain and odor remover that works to deep clean these types of surfaces without destroying them.

Expert TIp
Always clean up pet stains as soon as they occur. This prevents the odor and stain from setting into the carpet or materials. Fresh stains and odors are easier to remove.
BestReviews Cleaning Expert

Types of pet stain and odor removers

Detergent cleaners: These products are designed to work on carpets and upholstery, and many of them are compatible with or exclusively for use with carpet cleaners. These products tend to lather up, especially when used with a machine. Although these pet stain and odor removers may contain chemicals, you can find ones with biodegradable or less-toxic ingredients. Look for ones that follow the Safer Choice Standard of the Environmental Protection Agency (EPA).

Enzymatic cleaners: The beauty of most enzymatic pet stain and odor removers is that they’re safe to use on virtually any surface your pet has soiled. These work gently yet effectively without releasing harmful toxins into your home, making them naturally an eco-friendly and safe choice for households with pets and children.

  • How they remove stains: Enzymatic cleaners for pet stains mainly use biological compounds called enzymes to rapidly break down other biological compounds – the pet mess. These products are formulated with specific enzymes, such as protease, to tackle protein-based stains like urine and feces. As unpleasant as this sounds, these bio-enzymes “feed” on ammonia crystals and the organic matter of feces until they’re all gone. Enzymatic cleaners can provide a deeper clean than detergents because they get into every nook and cranny of the surface they’re working on.

  • How they remove odors: One downside of enzymatic cleaners is that they must dry completely to work, which can be a bit of a waiting game. The drying process is what eliminates the odor, so you might have to wait up to 24 hours to notice that the odor is gone. These longer-acting cleaners have a reputation for getting rid of odors more effectively than detergent cleaners because they actually break down the odor-causing bacteria rather than mask the smell.

How to use enzymatic pet stain and odor removers

When approaching a pet mess, you first want to remove or blot up as much of the surface solids or liquids as you can with paper towels. Depending on the product bottle, either spray or pour the cleaner directly onto the remaining stain. No need to rub or scrub. Let the enzymes “eat away” the mess. Most removers require that you leave them on the stain for five to ten minutes. Then use an absorbent towel to blot or wipe the area and allow to dry completely.

  • Carpets: For carpets, be sure to saturate the stain with solution so it reaches the carpet pad. Some solutions also require an application of water, particularly with urine stains, so be sure to read the manufacturer’s instructions before using.

  • Upholstery: Most pet stain and odor removers work on any surface, but for upholstered furniture, we recommend looking for a product that is certified safe for carpets by the Carpet and Rug Institute (CRI). It’s also recommended that you test the colorfastness of the fabric by applying the product to a hidden area (like the underside of a couch pillow). Allow it to sit for five minutes and wipe it away with a white cloth. If color appears on the cloth, you know you can’t safely use the product on your upholstery.

  • Laundry: You can use pet stain and odor removers as a prewash treatment.on clothes or bedding soiled by pets  Spray or pour the solution directly onto the stain and let it sit for up to ten minutes, without scrubbing, before putting the item in the washing machine.

  • Hardwood floors: Most enzymatic cleaners can be used on all surfaces, but some aren’t suitable for hardwood floors and other uncarpeted surfaces like concrete, tile, linoleum, and vinyl. Be sure to check the product’s label before using it on these surfaces.

  • Tougher stains: If you’ve let the enzymatic pet stain and odor remover dry completely and still smell the odor, you might need to repeat the process a couple times. This isn’t out of the ordinary. You can also leave the solution on longer – at least an hour – and cover it with a towel weighted down by an object to better absorb liquid out of the fabric.

Expert Tip
Store your pet stain and odor remover in a dry space, like a pantry, under a sink, or in a laundry area.
BestReviews Cleaning Expert

Pet stain and odor remover features

Spray vs. pour

Spray bottle: Spray bottles give you better control over how much of the solution you apply to a targeted area. Spray bottles usually contain 32 ounces. Although these bottles are generally used to deliver the solution through the spray nozzle, you can also unscrew the top and pour the solution directly on the stain.

Pour bottle: Pour bottles generally come with a larger volume of solution, typically a gallon. You pour the cleaner directly on the stain, making it harder to control the amount of solution you apply. However, this may be the best choice for tougher stains. Also, if you have lots of pets or a pet that has lots of accidents, you might prefer the larger bottle.    


A big consideration when it comes to pet stain and odor removers is the scent. Some products have strong, even overpowering scents and some are less bold. Which you use comes down to your preference. If you’re sensitive to scents, look for an unscented enzymatic cleaner.

Other features

Some detergent pet stain and odor removers come with additional perks like sanitizing properties, Scotchgard, or a brush head attached to the bottle for scrubbing.

Pet stain and odor remover prices

These products range in price from $5 to $40.

Spray bottles tend to be less expensive than pour bottles and cost from $5 for a budget product to $30 for a high-quality formula.

Expert Tip
After cleaning, allow all areas to fully dry.
BestReviews Cleaning Expert

Pour bottles come at a higher price point, between $20 and $40, but are an economical choice because they typically contain four times the amount in a spray bottle.  


  • Let the product dry. When using an enzymatic pet stain and odor remover, be sure to wait 24 hours for it to dry completely before vacuuming the area.

  • Avoid using hot or warm water with enzymatic cleaners. The enzymes don’t react well to extreme temperatures and won’t work effectively.

  • Use enzymatic cleaners at full strength. Most enzymatic cleaners shouldn’t be diluted with water. For tougher stains, look for a “concentrated” enzymatic cleaner, which contains more enzymes and is more effective.

  • Use a machine-formula product with a carpet or steam cleaner. These tend to be more detergent-based solutions that come in pour bottles. We recommend that you avoid using enzymatic cleaners in machines because of the high temperatures used by these appliances.

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If your pet is urinating frequently in the house and not in the process of being housebroken, it might be time for a visit to the vet to see if your pet is suffering from a urinary tract infection.


Q. What is the shelf life of pet stain and odor removers containing enzymes?

A. Typically one to two years. Store enzymatic cleaners away from heat or freezing temperatures. And don’t forget to shake the bottle before use to activate the enzymes!

Q. Is it safe for paws and little feet to be around pet stain and odor removers?

A. Enzymatic cleaners are safe for pets and children to be around. You might want to cover the treated area with a towel while the solution is working. Not all detergent-based cleaners are safe for little ones and creatures. Those with biodegradable ingredients tend to be safer, but the safest bet is to use an enzymatic solution. All household cleaners should be stored where children and pets can’t gain access.  

Q. Should I scrub the site of the pet mess with these cleaners?

A. You certainly can, and detergent cleaners may require it so the solution penetrates more deeply. For enzymatic cleaners, let the solution soak in first before you scrub. You may find that the enzymes do the work for you and save you some elbow grease.