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Best Pain Relief Creams

Updated November 2023
Bottom line
Pros
Cons
Best of the Best
Topricin Pain Relief Cream
Topricin
Pain Relief Cream
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Customer Favorite
Bottom Line

A potent blend of effective pain-relieving ingredients that works to heal and relieve symptoms for a variety of needs.

Pros

This unique formula targets inflammation that causes pain for fast and lasting relief. Effective treatment for arthritis, joint and muscle pain, injuries, nerve pain, and more. Can be used to treat bruises and minor cuts and scrapes.

Cons

The vast majority of feedback is positive, though a few wish it came at a lower price point.

Best Bang for the Buck
Arnicare Pain Relief Cream
Arnicare
Pain Relief Cream
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Homeopathic Remedy
Bottom Line

A soothing, quality cream with a plant-based active ingredient to ease pain and discomfort.

Pros

Provides fast and effective relief for soreness and joint and muscle pain and stiffness. Reduces bruising and swelling. Topical cream is light, non-greasy, and unscented. Safe, homeopathic formula works with the body and is gentle enough for sensitive skin.

Cons

Some report experiencing less pain relief effects than with other comparable products.

Aspercreme Pain Relieving Cream
Aspercreme
Pain Relieving Cream
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Trusted Brand
Bottom Line

A clinically proven pain relief treatment that is great for easing arthritis and pain in joints and muscles.

Pros

Proven to ease joint and muscle pain and aches. Convenient and discreet with an odor-free, non-greasy formula. Made with aloe and other moisturizers for additional moisturizing and soothing benefits.

Cons

Some don’t like the texture of the cream.

Bengay Ultra Strength Topical Pain Relief Cream
Bengay
Ultra Strength Topical Pain Relief Cream
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For Minor Aches
Bottom Line

According to our medical expert, this pain relief cream is more effective for treating minor pain than arnica cream.

Pros

This cream is non-greasy and contains camphor, menthol, and methyl salicylate for pain relief. It's best for treating backaches, minor arthritis, and muscle pain. Easy to rub in and apply.

Cons

Pain-killing effects don't last as long as other pain relief creams.

Penetrex Pain Relief Cream
Penetrex
Pain Relief Cream
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Expert Recommended
Bottom Line

A professional-grade cream that cures inflammation to thwart pain.

Pros

Its primary ingredients work wonders for inflammation, which is the common cause for most pain. It avoids any burning sensations when applied, making it great for those with sensitive skin. It's not too greasy and has a mildly pleasant smell that doesn't linger.

Cons

Some users would prefer a stronger formula with quicker results.

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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews 
HOW WE TESTED

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

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Buying guide for Best pain relief creams

Oh, your aching muscles and sore joints. Whether you went too hard at your workout, spent an afternoon moving heavy boxes, or just suffer with the misery of arthritis, just about everyone occasionally needs sweet relief from simple aches and pains. To the rescue: pain relief creams.

These topical treatments are sold over the counter and contain a wide range of ingredients that help relieve minor to moderate pain in a variety of ways. Some heat up; others cool down. Some reduce inflammation; others block pain receptors so they can’t send signals to your brain telling it that something hurts.

However, while there’s a pain relief cream for just about every kind of ache, the choices can be quite overwhelming when you’re facing multiple choices at the drugstore or online pharmacy. That’s why we’ve taken the headache out of understanding, choosing, and using the right pain relief cream for your needs.

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There are many active ingredients used in OTC pain-relieving creams. Some work by reducing pain signals to the brain, some distract nerves, and some reduce inflammation.

What’s in a pain relief cream?

Most pain relief creams have a lotion-like and somewhat moisturizing base. They often contain mineral oil, glycerin, and other ingredients that are easy on the skin and absorb well without leaving a greasy or sticky film. The majority of these products are sold in a tube, but you’ll also find pump dispensers, jars, and even roll-on formats.

However, it’s the active ingredients that really distinguish one product from another, and there are quite a few different active ingredients you’re likely to find on drugstore shelves. These ingredients fall into five basic groups: salicylates, anesthetics, capsaicin, counterirritants, and hemp oil or CBD. Many pain-relieving creams combine two or more ingredients from more than one category.

Salicylates

Salicylate, or salicylic acid, is the active metabolite in aspirin. It’s often included in pain-relieving creams in the form of wintergreen oil, which has a distinct and strong fragrance. This pain buster helps relieve discomfort by reducing inflammation and swelling. It’s especially good for muscle pain caused by overuse or arthritic joint pain. When applied topically, the salicylic acid penetrates the skin to reduce pain and swelling inside achy joints. People who are sensitive or allergic to aspirin should not use pain-relieving creams containing salicylates.

Expert tip
If the use of cream does not provide relief over several days, consult a doctor to determine why you have pain and what are other treatment options.
BestReviews Medical Expert

Anesthetics

Anesthetics numb the treated area, reducing pain signals sent to the brain. The common anesthetic used in OTC pain relievers is lidocaine. It’s an effective treatment for musculoskeletal pain caused by arthritis or overuse injuries.

Capsaicin

Capsaicin is the naturally occurring substance in chili peppers that gives them their fiery bite. When applied topically, capsaicin stimulates a feeling of heat on the skin, which can be intense at first. But the biggest benefit comes from capsaicin’s ability to block pain signals from traveling between irritated nerves and the brain. It can take a few days of regular application before you’ll feel the full benefits of capsaicin cream. These creams are especially effective for treating diabetic nerve pain and arthritic joint pain.  

Counterirritants

There are several active ingredients commonly used as counterirritants, including menthol, camphor, eucalyptus, and oil of evergreen. Counterirritants don’t directly act on swollen or inflamed muscles and joints; instead, they create simultaneous sensations of coolness and warmth on the skin, which distracts your nerves and cuts down on perceived pain. These are helpful treatments for overuse injuries and minor muscle pain.

Hemp oil and CBD

Not to be confused with THC, the component of marijuana that gets you high, CBD (cannabidiol), which is often extracted from hemp oil, is said to relieve muscle and joint pain when applied topically by reducing inflammation and desensitizing pain receptors. CBD pain-relieving creams are often recommended for arthritis and fibromyalgia pain.

Expert tip
Wash your hands after each application or, even better, use gloves or a disposable applicator to apply pain relief cream.
BestReviews Medical Expert

Pain relief cream prices

The majority of pain relief creams cost less than $25, and many cost under $10. As a general rule, you’ll pay more for creams containing capsaicin, CBD, or herbal active ingredients and less for those containing just counterirritants or lidocaine.

Tips

Many people assume that because a medication is sold over the counter, it must be safe to use in any fashion. Although you aren’t likely to be injured by an OTC pain-relieving cream, you’ll get the best results by following these tips.

  • Follow the package directions. Don’t apply the treatment more frequently, or for a longer time, than recommended. And unless directed by a medical professional, don’t apply a pain-relieving treatment to a baby or toddler.
  • Don’t apply the treatment to irritated skin. Avoid sores, rashes, blisters, and burns.
  • If you need to apply a bandage over the area being treated, keep the bandage loose. Remove it periodically to let your skin breathe.
  • Use with caution. Keep the cream away from your eyes, nostrils, mouth, and genital region. Wash your hands before and after applying the cream.
  • If you are on prescription blood thinners or taking daily aspirin, check with your doctor before applying a pain relief cream that contains salicylates. This ingredient could increase the effects of blood thinners.
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Pain relief creams are best for muscular or joint pain that’s near the surface of the skin. They aren’t intended for deep pain in the abdomen, pelvis, or chest.
Expert tip
Keep cream at room temperature.
BestReviews Medical Expert

FAQ

Q. Do pain-relieving creams really work?

A. While you won’t get the kind of pain relief from an OTC pain relief cream that you’d get from a prescription medication or an oral pain reliever, these treatments can provide quite a bit of relief for minor pain in the joints and muscles. They are especially good for treating arthritis pain, bursitis, tendonitis, sore muscles from overuse, bruised or swollen joints, and minor strains and sprains.

Q. What should I do if the pain-relieving cream doesn’t help?

A. If you’ve used a pain relief cream as directed for a week without improvement, it’s time to call your doctor. She can prescribe stronger medications or check for more serious conditions that require a different type of treatment.

Q. Are pain-relieving creams safe for everyone?

A. As a general rule, these treatments are safe for most people. If you are on prescription blood thinners, however, stay away from creams containing salicylates as the active ingredient, as this can cause bleeding or bruising. Pain-relieving creams should not be used on infants or toddlers.

Side effects are rare but may include burning, itching, or a rash at the application site. If you experience any type of skin irritation or rash while using a pain relief cream, stop applying the product, and see your doctor if the irritation doesn’t clear up within a few days.