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Best Cholesterol-Lowering Supplements

Updated January 2023
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Best of the Best
ZOI Research Cholesterol Support
ZOI Research
Cholesterol Support
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Clinically Backed
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A proprietary blend of nutrient-dense, clinically studied ingredients that support healthy lipid metabolism.


Packed with natural ingredients known to support healthy cholesterol levels such as soluble fiber, plant sterols, policosanol, and proprietary vegetable blend. Rigorous testing practices ensure optimum quality.


Most users are very satisfied with efficacy, but a few reported minimal changes in their cholesterol levels.

Best Bang for the Buck
Kyolic Aged Garlic Extract
Aged Garlic Extract
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Power of Garlic
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Provides all of the cholesterol-supporting benefits of garlic in a concentrated, odorless, and convenient capsule.


Contains 600 mg of aged garlic to support healthy cholesterol levels, as well as heart, immune, and liver function. Made from organic garlic that has been aged up to 20 months to enhance nutritional value and make it gentle for digestion. Quality ingredients are free of pesticides, herbicides, and chemical fertilizers.


Capsules aren't easy to swallow.

Bluebonnet CholesteRice
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Trusted Brand
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A formula designed to promote healthy cholesterol levels made by a brand known and trusted for quality supplements.


Ingredients work together to promote cardiovascular health and optimal cholesterol levels. Vegan, non-GMO, and free of most common allergens. Formulated for maximum absorption and assimilation.


Some feel the capsules are hard to swallow.

Wiley’s Finest Wild Alaskan Fish Oil Cholesterol Support
Wiley’s Finest
Wild Alaskan Fish Oil Cholesterol Support
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Quality Ingredients
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Top-quality fish oil works together with plant sterols to support heart health and block absorption of cholesterol.


Sustainably sourced fish oil made from wild Alaskan Pollock promotes heart health and optimum cholesterol and triglyceride levels. Pine tree sterols provide additional cholesterol level management benefits. No odor or unpleasant aftertaste.


Won’t work for vegetarians and vegans.

BRI Nutrition Odorless Garlic
BRI Nutrition
Odorless Garlic
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Customer Favorite
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A premium supplement that helps people maintain normal cholesterol levels, bolster the immune system, and much more.


Has been shown to help people keep their blood pressure under control and reduce elevated blood pressure within days after first use. Softgels are easy to swallow. Contains parsley seed to help freshen the breath. A true odorless garlic supplement.


Some garlic burps may occur after initial use.

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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews 

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

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Buying guide for best cholesterol-lowering supplements

Maybe your doctor has warned you that your cholesterol is too high. Maybe you’re simply concerned about keeping your heart and circulatory system as healthy as possible. In either case, you may have wondered if there are alternatives to cholesterol-lowering prescription drugs. In fact, there are several natural alternatives that have proven effective in some studies.

You’ll find a lot of cholesterol-lowering supplements on sale today, and with these products comes a lot of marketing hype. It’s hard to know what to believe. That’s why we created this guide: to help our readers choose the right cholesterol-lowering supplements.

Read on for more information!

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High cholesterol is one of the most common health factors that can increase a person’s heart attack and stroke risk.

What is cholesterol?

From the bad rap high cholesterol gets, you might assume that all cholesterol is bad – or that cholesterol is foreign to your body. Actually, cholesterol is found in every cell of your body and is critical to your health. This waxy, yellowish fat is a building block of the membrane surrounding each of your cells. It also plays a role in producing vitamin D, hormones, and bile, which helps your body digest fat.

Another common misconception about cholesterol is that it primarily comes from the foods you eat. In truth, your liver and intestines produce the majority of cholesterol in your body – around 80%. Only the remaining 20% comes from your diet. Animal products such as meat, eggs, and dairy contain cholesterol.

Good cholesterol vs. bad cholesterol

When your doctor checks your cholesterol with a blood test called a lipid panel, the results aren’t simply one number. A full picture of your cholesterol level – and whether or not it needs lowering – comes from four separate but related values: LDL, HDL, triglycerides, and total blood cholesterol.


LDL, often referred to as bad cholesterol, stands for low-density lipoprotein. LDL transports cholesterol through your bloodstream to your cells. The “bad” part of LDL is that in high levels, it tends to build up fatty plaques inside your arteries – a condition called atherosclerosis. Atherosclerosis reduces blood flow through the affected arteries, leading to an increased risk of heart and kidney disease, peripheral artery disease, stroke, heart attack, and blood clots. For adults, a healthy LDL level is less than 100 mg/dl.


HDL, or high-density lipoprotein, is often referred to as good cholesterol. It helps remove LDL from your bloodstream by carrying it back to the liver, where it’s broken down for excretion. Thus, HDL helps protect your heart from disease and lowers your risk of stroke. A healthy HDL level for adults is more than 60 mg/dl.


Triglycerides are a type of fat that stores excess energy from the calories you consume. A high level of triglycerides indicates an increased risk of stroke and heart disease. A triglyceride blood test result above 150 mg/dl is considered too high.

Total blood cholesterol

Your total blood cholesterol combines the levels of HDL, LDL, a portion of your triglycerides, and some other fatty proteins into a single number that renders an overall picture of your blood lipid levels. Healthy adults should have a total blood cholesterol level below 200 mg/dl.

Supplements to lower cholesterol

Two of the most effective ways of boosting HDL and lowering LDL are exercising and eating a healthy diet. Consuming too much saturated fat and trans fat – found in red meat, dairy products, and processed foods – can increase your level of unhealthy cholesterol. Consuming too little unsaturated fat – found in nuts, seeds, fish, and vegetable oils – can do the same.

If your LDL levels are very high or you’re at higher risk for heart disease for another reason, your doctor may prescribe a medication to lower your cholesterol. Usually, this medication is a statin drug. If you’d like to try a more natural approach or cannot tolerate statins, however, you may wish to consider the many foods and food-derived substances that have been shown to lower cholesterol.

You’ll find a dizzying array of cholesterol-lowering supplements for sale; some combine several active ingredients and others contain just one. The following are some of the most promising natural supplements that are thought to help lower cholesterol.


Niacin, also known as vitamin B3, is so effective at lowering LDL while boosting HDL that it’s often prescribed by doctors in high doses. Over the counter, you’ll find low-dose supplements that may also be effective. Niacin can cause facial flushing, and in high doses, it may harm your liver. Check with your doctor before taking a high-dose niacin supplement.

Omega-3 fish oil

Omega-3 fish oil has proven quite effective at lowering triglyceride levels, raising HDL, and promoting overall heart health. While you can get a hefty dose of omega-3 fatty acids by eating fish – particularly salmon, sardines, and herring – most people prefer taking it in supplement form for convenience.

Psyllium husks

Psyllium husks and other soluble fibers whisk LDL out of your bloodstream and help regulate your digestive system. You can stir psyllium into a glass of water and drink it or enjoy a bowl of oatmeal for breakfast.

Plant sterols

Plant sterols are found naturally in many vegetables, fruits, nuts, and grains. Something like a plant cholesterol, they block the absorption of dietary cholesterol and lower the amount of LDL in your blood.


Policosanol is a chemical derived from sugarcane, wheat germ, or beeswax. While studies are mixed, it seems to lower LDL and reduce the production of cholesterol in the liver.

Red yeast rice extract

Red yeast rice extract contains a natural, low-dose form of lovastatin, a prescription medication used to lower cholesterol. It can lower LDL very effectively, but take care when choosing a red yeast rice extract; some less-reputable manufacturers claim amounts of the extract that aren’t actually in the product.


Garlic isn’t just delicious in your cooking; it’s also healthy for your heart. Some studies have shown garlic to lower levels of LDL and total cholesterol. It may also reduce the amount of cholesterol produced by your liver.


Guggul extract comes from the resin of the Mukul myrrh tree. It’s been used in India for thousands of years for a variety of desired health benefits, including lowered cholesterol. While results have been mixed, some studies suggest it can reduce total cholesterol.

Soy protein

Soy protein doesn’t have a tremendous effect, but it can lower your total cholesterol and LDL slightly. Replacing one or two meat dishes each week with a soy protein is an easy boost to your health.

Cholesterol-lowering supplement prices

Typically, you’ll pay between $10 and $40 for a bottle of cholesterol-lowering capsules. If you opt for a simple formula with one or two touted benefits, you will likely pay closer to the $10 mark. However, if you go for a complex formula that addresses more than one health condition, you may end up paying closer to $40 per bottle. For example, there are some cholesterol-lowering supplements that advertise benefits beyond lowering cholesterol, such as improved physical endurance and mental concentration. This type of product is likely to cost more than a simpler formula.

Pay attention to the per-pill cost of the supplement as well as how many supplements you should take per day. If the manufacturer does not provide a per-pill cost, calculate it yourself by dividing the price by the number of pills in the bottle. Many bottles come with 60 to 120 capsules that, if taken regularly, will last a month or more depending on how many are consumed per day.

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As the FDA does not regulate dietary supplements, it’s best to stick with reputable brands that use ingredients you can trust.


Q. Do cholesterol-lowering supplements really work?

A. Yes, there are rigorous studies showing that many of the most popular supplement ingredients do indeed help reduce levels of LDL, increase levels of HDL, and lower total cholesterol. Omega-3 fatty acids, soluble fiber such as psyllium, plant sterols, and niacin have particularly strong results in studies, but some other common ingredients have shown mixed results in lowering blood cholesterol levels as well.

Q. Should I take a single-ingredient product or a combination product to lower my cholesterol?

A. While both have benefits, you are less likely to experience side effects or other issues if you stick with a single-ingredient product. Also, if you take a single-ingredient supplement and blood tests reveal your cholesterol levels have improved, you’ll know that the ingredient provided the benefit.

Q. Does a higher price always indicate higher quality when it comes to cholesterol-lowering supplements?

A. No, not always. Because there are so many different ingredients and formulas that can lower cholesterol, the price range for these supplements is vast. As a general rule, you may wish to stick with well-known brands that use proven ingredients, avoiding bargain-basement prices from lesser-known companies.

Q. Should I be concerned about side effects when taking a cholesterol-lowering supplement?

A. While most of the ingredients used in these products are free of side effects, some people do occasionally have sensitivities or problems with certain ingredients. Guggal and policosanol, for instance, upset some people’s stomachs, while psyllium and other high-fiber products might cause bloating or gas. Niacin causes facial flushing in some people, and in rare instances, it can damage the liver in high doses.