Best Pet Antifungal Medications

Updated October 2020
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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. Read more  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.Read more 
Bottom Line
Pros
Cons
Best of the Best
Fluconazole Generic Tablets
Fluconazole
Generic Tablets
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Tackles Major Fungus
Bottom Line

Despite possible side effects, this medication may be the only one that works for a variety of major fungal and yeast infections in dogs and cats.

Pros

A trusted and effective antifungal medication that treats numerous types of serious fungal and yeast infections, including ringworm outbreaks. Can be prescribed for dogs and cats.

Cons

Several side effects are possible, but worth the risk if your pet has a major fungal infection that won't respond to other medications. Not for animals that are pregnant/nursing or have liver diseases. Requires a prescription from a vet.

Best Bang for the Buck
Tresaderm Topical Solution for Dogs & Cats
Tresaderm
Topical Solution for Dogs & Cats
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Best for Skin Fungus
Bottom Line

When it comes to treating ears and skin for a multitude of fungal and other infections, Tresaderm is a popular treatment that's known for its effectiveness in both dogs and cats.

Pros

Versatile, as it contains an antifungal, steroid, and antibiotic for treating fungal infections and more. Treats the skin and ears of both dogs and cats. Calms inflammation that occurs simultaneously with infections. Highly effective for most pets.

Cons

Requires a vet prescription. Can sting a bit when first administered, especially in the ears. Although rare, some other side effects may occur.

Itrafungol Oral Solution for Cats
Itrafungol
Oral Solution for Cats
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Treats Feline Fungus
Bottom Line

Although giving it to some cats may be challenging, this oral medication is the one to get for a stubborn feline ringworm infestation.

Pros

Targets ringworm in cats before it spreads, and is effective in areas where outbreaks are common, including the skin and nails. Promotes regrowth of fur where ringworm has occurred. Flavored to be more appealing to finicky felines. Comes with a dosing syringe.

Cons

Some cats experience digestive upset and emotional issues while taking it. Prescription required. Can be difficult to give to cats that are opposed to taking oral medications. Not for dogs.

Otomax Gentamicin Betamethasone Clotrimazole Otic Ointment for Dogs
Otomax
Gentamicin Betamethasone Clotrimazole Otic Ointment for Dogs
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Dog Ear Ointment
Bottom Line

Fungal ear infections in dogs often require prescription-strength medication to treat, and this 3-in-1 ointment works well for most canines.

Pros

A powerful medication for canine fungal ear infections that includes antibacterial and steroidal properties. Earns praise from customers for being effective and working quickly. Long, thin applicator makes application easy. Fast shipping.

Cons

Requires a prescription from a vet. Side effects are fairly rare, but some are possible. Not for cats.

Tetra Lifeguard All-in-One Bacterial & Fungus Treatment
Tetra
Lifeguard All-in-One Bacterial & Fungus Treatment
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For Aquarium Hobbyists
Bottom Line

If you are fighting fungus in your fish tank or are looking for an effective preventative, this is the antifungal medication to choose for your finned pets.

Pros

Benefits the health of your aquarium fish, as it can be used as both a preventative and treatment. Treats fungus and other conditions, including mouth rot and ick. Can prevent outbreaks. Pre-measured doses eliminates dosing guesswork.

Cons

Only suitable for fish with scales, so you'll have remove other aquatic life such as crustaceans and mollusks from your tanks prior to treatment.

How we decided

We purchase every product we review with our own funds — we never accept anything from product manufacturers.

33 Models Considered
18 Hours Researched
2 Experts Interviewed
155 Consumers Consulted
Zero products received from manufacturers.

We purchase every product we review with our own funds — we never accept anything from product manufacturers.

Just like humans, pets can develop fungal infections. Dogs and cats can get yeast infections of the ears, suffer fungal growth around the nails, and are susceptible to skin fungus including the dreaded ringworm infestation that can easily be transmitted to humans. Fish are also prone to developing fungal infections on their fins. No one likes to think about these microscopic pests making their pets uncomfortable, but effective treatments are available. Finding the antifungal medication that works best for your pet’s fungal infection typically requires the diagnosis of a veterinarian. But once you know what medication will tackle the problem, you and your best friend can get back to normal.

Other Products We Considered
The BestReviews editorial team researches hundreds of products based on consumer reviews, brand quality, and value. We then choose a shorter list for in-depth research and testing before finalizing our top picks. These are the products we considered that ultimately didn't make our top 5.
Veterinary Formula Clinical Care
Antiseptic and Antifungal Spray
BEXLEY LABS
Curaseb Antifungal & Antibacterial Spray
Arava - Dead Sea Pet Spa
Medicated Dog Shampoo Antibacterial Antifungal
Pet MD
Antiseptic and Antifungal Medicated Spray
Jungle Pet
Antifungal + Antibacterial Flush
Smiling Paws Pets
Antibacterial & Antifungal Shampoo For Dogs & Cats
BEXLEY LABS
Curaseb Chlorhexidine Wipes
RenuPlex
Antifungal Dog Hot Spot Spray
Pet MD
Antifungal Wipes for Skin Infections
Nootie
Antifungal Wipes Medicated
DechraTopical
TrizEDTA Flush for Dogs & Cats Antifungal
Aquarium Pharmaceuticals Inc.
Pimafix Antifungal Fish Treatment
MOKAI
Antifungal and Dermatological Treatment
Nootie
Medicated Dog Shampoo: Antifungal
Forticept
Maxi-Wash Antifungal Antibacterial Medicated
Pet Health Pharma
Truseb Dogs,Cats Antifungal & Antiseptic Medicated
SOBAKEN
Antifungal Fish Medication
Veterinary Formula Clinical Care
Dogs and Cats Antifungal Medicated
VetWELL
Antifungal & Antiseptic Medicated Pet Wipes
See more
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Tetra

Lifeguard All-in-One Bacterial & Fungus Treatment

Tetra

Lifeguard All-in-One Bacterial & Fungus Treatment

If you are fighting fungus in your fish tank or are looking for an effective preventative, this is the antifungal medication to choose for your finned pets.

$6

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Our Top Picks
Fluconazole Generic Tablets
Best of the Best
Fluconazole
Generic Tablets
Shop Now
Tresaderm Topical Solution for Dogs & Cats
Best Bang for the Buck
Tresaderm
Topical Solution for Dogs & Cats
Shop Now
Itrafungol Oral Solution for Cats
Itrafungol
Oral Solution for Cats
Shop Now
Otomax Gentamicin Betamethasone Clotrimazole Otic Ointment for Dogs
Otomax
Gentamicin Betamethasone Clotrimazole Otic Ointment for Dogs
Shop Now
Tetra Lifeguard All-in-One Bacterial & Fungus Treatment
Tetra
Lifeguard All-in-One Bacterial & Fungus Treatment
Shop Now