5 Best Pet Antifungal Medications - Oct. 2026

BEST OF THE BEST

Itrafungol

Oral Solution for Cats

Liquid Ringworm Medicine

An oral medication that quickly eliminates ringworm and eases symptoms.

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PROS

Liquid medication is easy to give to cats and quickly eases symptoms of ringworm on the skin.
Also quickly eliminates ringworm altogether, which is important since it is so contagious.

CONS

Can cause vomiting and diarrhea in some cats.

BEST BANG FOR THE BUCK

Tresaderm

Topical Solution for Dogs & Cats

Best for Skin Fungus

When it comes to treating ears and skin for a multitude of fungal and other infections, Tresaderm is a popular treatment that's known for its effectiveness in both dogs and cats.

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PROS

Versatile, as it contains an antifungal, steroid, and antibiotic for treating fungal infections and more.
Treats the skin and ears of both dogs and cats.
Calms inflammation that occurs simultaneously with infections.
Highly effective for most pets.

CONS

Requires a vet prescription.
Can sting a bit when first administered, especially in the ears.
Although rare, some other side effects may occur.

Otomax

Betamethasone Clotrimazole Otic Ointment for Dogs

Dog Ear Ointment

Fungal ear infections in dogs often require prescription-strength medication to treat, and this 3-in-1 ointment works well for most canines.

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PROS

A powerful medication for canine fungal ear infections that includes antibacterial and steroidal properties.
Earns praise from customers for being effective and working quickly.
Long, thin applicator makes application easy.
Fast shipping.

CONS

Requires a prescription from a vet.
Side effects are fairly rare, but some are possible.
Not for cats.

Tetra

Lifeguard All-in-One Bacterial & Fungus Treatment

For Aquarium Hobbyists

If you are fighting fungus in your fish tank or are looking for an effective preventative, this is the antifungal medication to choose for your finned pets.

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PROS

Benefits the health of your aquarium fish, as it can be used as both a preventative and treatment.
Treats fungus and other conditions, including mouth rot and ick.
Can prevent outbreaks.
Pre-measured doses eliminates dosing guesswork.

CONS

Only suitable for fish with scales, so you'll have remove other aquatic life such as crustaceans and mollusks from your tanks prior to treatment.

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First Reviewed

November 09, 2021

Models
considered

Hours
researched

Written by Jennifer Manfrin

Updated March 2024

Just like humans, pets can develop fungal infections. Dogs and cats can get yeast infections of the ears, suffer fungal growth around the nails, and are susceptible to skin fungus including the dreaded ringworm infestation that can easily be transmitted to humans. Fish are also prone to developing fungal infections on their fins. No one likes to think about these microscopic pests making their pets uncomfortable, but effective treatments are available. Finding the antifungal medication that works best for your pet’s fungal infection typically requires the diagnosis of a veterinarian. But once you know what medication will tackle the problem, you and your best friend can get back to normal.

Best Pet Antifungal Medications

Pros and Cons

Pros and Cons

Pros and Cons

Pros and Cons

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