5 Best Dog Skin & Coat Medications - June 2026

This tablet effectively reduces itch and inflammation associated with allergy-related skin conditions and is easy to give to most dogs.

Check Price at Chewy.com View at Chewy.com

PROS

Its active ingredient, ilunocitinib, reduces the skin's inflammatory response caused by allergies.
It treats both allergic dermatitis and atopic dermatitis.
It only needs to be taken once a day and can be administered with or without food.

CONS

It requires a prescription.
Its side effects include tiredness, vomiting and diarrhea.

BEST BANG FOR THE BUCK

Nutramax

Welactin Canine Omega-3 Liquid Dog Supplement

Skin-nourishing Formula

A drug-free option to ease your dog's skin and coat problems. It's a plus that most dogs love the flavor.

Check Price Check Price

PROS

A supplement that is effective at calming itchy skin for most canines.
Makes fur soft and shiny.
Made with fish oil that's packed with omega-3 fatty acids that are beneficial to the skin.
The liquid form is easy to give with food.
No prescription required.

CONS

Not ideal for serious skin problems, and won't treat infections.
Some reports of leaky bottles.

Derm-Tabs

Regular Strength Liver Flavored Chewable Tablet Skin & Coat Supplement for Dogs

Easy to Administer

These flavored tablets make it easy to keep your dog's skin and coat healthy and itch-free with a blend of natural ingredients.

Check Price at Chewy.com View at Chewy.com

PROS

It features a blend of vitamins, minerals and natural oils, as well as antioxidants and omega-3 and omega-6 fatty acids, that help keep the skin and coat healthy and reduce excessive shedding.
The tablets feature a liver flavor that dogs love.

CONS

There are sometimes moisture issues with the packaging, which can leave some of the tablets unusable.

Vetnique Labs

Dermabliss Medicated Anti-Bacterial & Anti-Fungal Chlorhexidine Infection Dog & Cat Skin Spray

For Bacterial and Fungal Infections

This easy-to-use spray can help soothe infections like yeast dermatitis, making your dog more comfortable in just a few days.

Check Price at Chewy.com View at Chewy.com

PROS

Its active ingredients treat both bacterial and fungal skin infections in dogs.
Its spray formula makes it very easy to apply.
It helps eliminate odors associated with skin infections.
It is made in the United States.

CONS

Some users complain that the spray mechanism can get stuck and cause a mess during application.

Bark&Spark

Soft Chewable Omega-3 Supplement, 180 Pieces

Easiest to Use

Easy-to-use and chewable, these chicken-flavored supplements support healthy hips and joints alongside dry and itchy skin.

Check Price Check Price

PROS

Packed with omega-3, which is great for irritated skin.
Dogs who don't like creams and lotions can chew this product like a treat.
You receive up to a three-year supply of treats.
They aim for a natural flavor that won't be off-putting to picky eaters.

CONS

Some dogs still don't like the salmon flavor of this product, but most appear to enjoy it.

Why trust BestReviews?

BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews

BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews

How We Tested

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

Click here for testing insights

First Reviewed

November 09, 2021

Models
considered

Hours
researched

Written by Jennifer Manfrin

Updated May 2025

Ready to buy now? Shop the best:

Best of the Best: Zenrelia (ilunocitinib tablets) for Dogs
Best Bang for the Buck: Nutramax Welactin Omega-3 Fish Oil Skin and Coat Health Supplement
Easy to Administer: Derm-Tabs Regular Strength Liver Flavored Chewable Tablet
For Bacterial and Fungal Infections: Vetnique Labs Dermabliss Medicated Anti-Bacterial & Anti-Fungal Chlorhexidine Infection Dog Skin Spray
Easiest to Use: BARK&SPARK Omega 3 for Dogs

The majority of pooches experience skin issues during their lifetimes. Parasites, immune system issues, and allergies are some of the most common agitators that can cause skin to become red, itchy, and even infected. When these problems occur, canine coats suffer too, resulting in loss of fur, odors, and dull, dry coats. But there's no need to stress if your dog has a troubling skin or coat condition, because there are medications that can help relieve symptoms as well as improve your pet's coat. Start by consulting with your veterinarian to find the medication that will work best for your dog's problem. Keep in mind that some medications require prescriptions to purchase.

Best Dog Skin & Coat Medications

Pros and Cons

Pros and Cons

Pros and Cons

Pros and Cons

Pros and Cons

Shop Similar Products Get the best products related to our top picks