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Pets Health

Best Dog and Cat Antibiotics

Updated August 2025
Bottom line
Pros
Cons
Best of the Best
Dechra Clavacillin Tablets for Dogs & Cats
Dechra
Clavacillin Tablets for Dogs & Cats
Customer Favorite

This oral antibiotic takes care of skin, tissue, and respiratory infections in dogs and cats.

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Customer Favorite
Bottom Line

This oral antibiotic takes care of skin, tissue, and respiratory infections in dogs and cats.

Pros

Contains amoxicillin trihydrate/clavulanate potassium. It can also treat periodontal disease in dogs and UTIs in cats. Sourced from FDA-approved manufacturers and distributors.

Cons

It can possibly cause an allergic reaction.

Amoxi-Tabs (Amoxicillin) Tablets (or Solution) for Dogs and Cats
Amoxi-Tabs (Amoxicillin)
Tablets (or Solution) for Dogs and Cats
Excellent Value

Although it's not the strongest or most broad-spectrum antibiotic available, Amoxicillin is frequently prescribed for mild to moderate infections.

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Excellent Value
Bottom Line

Although it's not the strongest or most broad-spectrum antibiotic available, Amoxicillin is frequently prescribed for mild to moderate infections.

Pros

A moderate-spectrum antibiotic that's used to treat a wide range of infections in dogs and cats. Not as likely to cause digestive upset as some stronger antibiotics. Works well for upper respiratory issues.

Cons

Falls in the penicillin family, and some dogs and cats may have an allergic reaction.

Neo-Poly-Bac (Generic) Ophthalmic Ointment for Dogs & Cats
Neo-Poly-Bac (Generic)
Ophthalmic Ointment for Dogs & Cats
Treats Eye Infections

An effective treatment for pet eye infections that is tolerated well by most dogs and cats, and it makes most pets' eyes feel better as it works.

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Treats Eye Infections
Bottom Line

An effective treatment for pet eye infections that is tolerated well by most dogs and cats, and it makes most pets' eyes feel better as it works.

Pros

Formulated with neomycin, Polymyxin, and bacitracin to treat numerous types of eye infections in dogs and cats. Soothes irritation and calms swelling. Ointment is easy to use.

Cons

May sting slightly, but this sensation tends to fade fairly quickly for most pets.

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BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews 
How We Tested

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

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First Reviewed
November 09, 2021
30
Models
considered
16
Hours
researched
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Jennifer Manfrin
Written by Jennifer Manfrin

Updated August 2025

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Dogs and cats can acquire numerous types of infections that require treatment with antibiotics. Ear, mouth, skin, upper respiratory, urinary tract, gastrointestinal, and eye infections are some of the most common that usually respond well to these veterinarian-prescribed medications. Some antibiotics target certain infections and types of bacteria, while others are broad-spectrum. These drugs can be administered to the eyes and ears, applied topically, or given orally. The type your vet prescribes for your pet will depend on several factors, including the diagnosis, his age, and size. Keep in mind that you will need to follow the dosing instructions closely for proper treatment, otherwise the infection could worsen or reoccur. Many of these antibiotics require a prescription from your vet in order to place the order.

Our Top Picks
Dechra
Best of the Best
Dechra
Clavacillin Tablets for Dogs & Cats
Bottom Line
This oral antibiotic takes care of skin, tissue, and respiratory infections in dogs and cats.
Shop Now
Amoxi-Tabs (Amoxicillin)
Best Bang for the Buck
Amoxi-Tabs (Amoxicillin)
Tablets (or Solution) for Dogs and Cats
Bottom Line
Although it's not the strongest or most broad-spectrum antibiotic available, Amoxicillin is frequently prescribed for mild to moderate infections.
Shop Now
Neo-Poly-Bac (Generic)
Top Pick
Neo-Poly-Bac (Generic)
Ophthalmic Ointment for Dogs & Cats
Bottom Line
An effective treatment for pet eye infections that is tolerated well by most dogs and cats, and it makes most pets' eyes feel better as it works.
Shop Now
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