5 Best Cat Heartworm Medications - May 2026

The chewable tablet is easy to administer.
Broad-spectrum treatment of parasites including tapeworm, heartworm and hookworm.
Monthly treatment regimen.
Works well for allergy prone cats.

CONS

Soft packaging can damage pills during shipment.

NexGard

Combo Topical Medication

Versatile Choice

This topical treatment is great for cats who are averse to taking oral medication.

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PROS

It covers not only heartworm disease, but it is also for fleas, ticks, and all three of the big bad worms: hook, round and tape.
It comes in single-, three- and six-month doses and for kittens or adult cats.

CONS

Some cats strongly dislike the topical style of prevention.

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First Reviewed

November 08, 2021

Models
considered

Hours
researched

Written by Michael Pollick

Updated October 2024

Ready to buy now? Shop the best:

Best of the Best: Advantage Multi Topical Solution for Cats
Best Bang for the Buck: Revolution Topical Solution for Kittens & Puppies
Expert-Recommended: Revolution Topical Solution for Cats
Easiest to Use: Interceptor Flavored Tablet for Dogs & Cats
Versatile Choice: NexGard COMBO Topical for Cats

Heartworm is a very dangerous medical condition caused by parasitic worms that enter the cat's bloodstream through infected foods, fleas, or ticks. The best treatment for heartworm is prevention, and this is what prescription-grade heartworm treatments provide. Heartworm medications are often combined with flea and tick medications for a more comprehensive treatment plan, but they can also be sold as a separate product. It is important that cat owners remain vigilant when administering heartworm medication, and to look for any signs of a possible heartworm infestation in the cat's feces. An actual case of heartworm often requires more aggressive treatment from a veterinarian.

Best Cat Heartworm Medications

Pros and Cons

Pros and Cons

Pros and Cons

Pros and Cons

Pros and Cons

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