Menu
 

BestReviews is reader-supported and may earn an affiliate commission. Details

Pets Health

Best Cat Heartworm Medications

Updated October 2024
Bottom line
Pros
Cons
Best of the Best
Advantage Multi Topical Solution for Cats, 9.1-18 lbs, 6 treatments
Advantage Multi
Topical Solution for Cats, 9.1-18 lbs, 6 treatments
Customer Favorite

This broad-spectrum formula is most effective against flea infestations but also addresses heartworm in cats.

Check Price
Check Price at Chewy.com
Customer Favorite
Bottom Line

This broad-spectrum formula is most effective against flea infestations but also addresses heartworm in cats.

Pros

Addresses heartworms, fleas, and ticks with 1 treatment. Only requires 1 monthly application. Broad-spectrum approach. Also effective against ear mites. Minimal side effects were reported.

Cons

Expensive price point. Results vary from cat to cat.

Revolution Heartworm Topical Solution
Revolution
Heartworm Topical Solution
Ideal For Kittens

Some heartworm medications can be too strong for kittens, but this formula is ideal for younger cats and dogs.

Check Price
Check Price at Chewy.com
Ideal For Kittens
Bottom Line

Some heartworm medications can be too strong for kittens, but this formula is ideal for younger cats and dogs.

Pros

Safe to use on both puppies and kittens. Can be used in combination with other flea, tick, or parasite treatments. Minimal side effects were reported. Monthly treatment regimen. The topical formula is easy to apply.

Cons

Fleas can return after several weeks, especially in areas with high infestations.

Revolution Plus Topical Solution for Cats, 5.1-15 lbs
Revolution Plus
Topical Solution for Cats, 5.1-15 lbs
Expert-Recommended

This powerful topical solution covers a number of parasite-related issues, including mosquitoes, mites, and worms.

Check Price
Check Price at Chewy.com
Expert-Recommended
Bottom Line

This powerful topical solution covers a number of parasite-related issues, including mosquitoes, mites, and worms.

Pros

Also addresses ear mites and heartworms. Kills both adult fleas and eggs within hours of application. Effective for 30 days. Non-greasy formula dries quickly. Works well with both outdoor and indoor cats.

Cons

Can require months of treatment to reach maximum effectiveness.

Interceptor Tablets for Dogs 51-100 lbs & Cats 12.1-25 lbs, 6 treatments
Interceptor
Tablets for Dogs 51-100 lbs & Cats 12.1-25 lbs, 6 treatments
Easiest to Use

This heartworm preventative targets parasites specifically, not fleas or ticks.

Check Price
Check Price at Chewy.com
Easiest to Use
Bottom Line

This heartworm preventative targets parasites specifically, not fleas or ticks.

Pros

The chewable tablet is easy to administer. Broad-spectrum treatment of parasites including tapeworm, heartworm and hookworm. Monthly treatment regimen. Works well for allergy prone cats.

Cons

Soft packaging can damage pills during shipment.

NexGard Combo Topical Medication
NexGard
Combo Topical Medication
Versatile Choice

This topical treatment is great for cats who are averse to taking oral medication.

Check Price
Check Price at Chewy.com
Versatile Choice
Bottom Line

This topical treatment is great for cats who are averse to taking oral medication.

Pros

It covers not only heartworm disease, but it is also for fleas, ticks, and all three of the big bad worms: hook, round and tape. It comes in single-, three- and six-month doses and for kittens or adult cats.

Cons

Some cats strongly dislike the topical style of prevention.

Why trust BestReviews?
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We only make money if you purchase a product through our links, and all opinions about the products are our own. About BestReviews  
BestReviews spends thousands of hours researching, analyzing, and testing products to recommend the best picks for most consumers. We buy all products with our own funds, and we never accept free products from manufacturers.About BestReviews 
How We Tested

We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.

Click here for testing insights
First Reviewed
November 08, 2021
36
Models
considered
26
Hours
researched
Category cover

Shop Similar Products Get the best products related to our top picks

Petrodex Enzymatic Poultry Toothpaste
Petrodex
Enzymatic Poultry Toothpaste
Check Price
NaturVet Ear Wash with Tea Tree Oil
NaturVet
Ear Wash with Tea Tree Oil
Check Price
Nutramax 30 Count Proviable Health Supplement
Nutramax
30 Count Proviable Health Supplement
Check Price
Nusentia Probiotic Miracle Miracle Probiotic for Dogs
Nusentia Probiotic Miracle
Miracle Probiotic for Dogs
Check Price
Embark Dog DNA Test and Health Screening
Embark
Dog DNA Test and Health Screening
Check Price
Michael Pollick
Written by Michael Pollick

Updated October 2024

Ready to buy now? Shop the best: 

Heartworm is a very dangerous medical condition caused by parasitic worms that enter the cat's bloodstream through infected foods, fleas, or ticks. The best treatment for heartworm is prevention, and this is what prescription-grade heartworm treatments provide. Heartworm medications are often combined with flea and tick medications for a more comprehensive treatment plan, but they can also be sold as a separate product. It is important that cat owners remain vigilant when administering heartworm medication, and to look for any signs of a possible heartworm infestation in the cat's feces. An actual case of heartworm often requires more aggressive treatment from a veterinarian.

Our Top Picks
Advantage Multi
Best of the Best
Advantage Multi
Topical Solution for Cats, 9.1-18 lbs, 6 treatments
Bottom Line
This broad-spectrum formula is most effective against flea infestations but also addresses heartworm in cats.
Shop Now
Revolution
Best Bang for the Buck
Revolution
Heartworm Topical Solution
Bottom Line
Some heartworm medications can be too strong for kittens, but this formula is ideal for younger cats and dogs.
Shop Now
Revolution Plus
Top Pick
Revolution Plus
Topical Solution for Cats, 5.1-15 lbs
Bottom Line
This powerful topical solution covers a number of parasite-related issues, including mosquitoes, mites, and worms.
Shop Now
Interceptor
Top Pick
Interceptor
Tablets for Dogs 51-100 lbs & Cats 12.1-25 lbs, 6 treatments
Bottom Line
This heartworm preventative targets parasites specifically, not fleas or ticks.
Shop Now
NexGard
Top Pick
NexGard
Combo Topical Medication
Bottom Line
This topical treatment is great for cats who are averse to taking oral medication.
Shop Now
Related Reviews
Show More
Related Articles
Show More
You Might Also Like
Show More