Best Enzymatic Cleaners

Updated October 2021
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We recommend these products based on an intensive research process that's designed to cut through the noise and find the top products in this space. Guided by experts, we spend hours looking into the factors that matter, to bring you these selections.


Buying guide for best enzymatic cleaners

There are plenty of cleaning products on the market that promise a clean house, but they’re often loaded with chemicals. If you’re looking for a non-toxic alternative to the usual household cleaning products, consider an enzymatic cleaner. Enzymatic cleaners use biological compounds to break down messes, stains, and odors around your home.

Choosing the right enzymatic cleaner can be tough if you’re not sure what to look for, however. With so many of these eco-friendly cleaners on the market, how do you find the best formula for your home?

At BestReviews, our goal is to make shopping easy for you. We buy our own products rather than accepting free gifts from manufacturers, which allows us to provide honest and unbiased recommendations. To compile our shopping guides, we test products in our labs and the field, consult our team of experts, and analyze customer feedback, so we can pass on the information you need to make the best shopping decisions.

If you’re ready to buy an enzymatic cleaner, check out our top picks. For more on what to look for before you buy an enzymatic cleaner, keep reading.

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Unlike traditional cleaners, enzymatic cleaners don’t release toxic fumes, making them a much safer, eco-friendly cleaning option.

What are enzymatic cleaners?

Enzymatic cleaners contain enzymes that break down the biological components in the messes around your home.

Enzymes are biological compounds that increase the speed at which other biological substances like starches, oils, fats, and proteins break down, so you can wipe away messes easily.

What are the benefits of enzymatic cleaners?

  • Non-toxic

Enzymatic cleaners are safer for both people and animals than traditional cleaning products. You don’t have to worry about enzymatic cleaners affecting the health of any members of your household.

  • Eco-friendly

Because they contain natural, non-toxic ingredients, enzymatic cleaners are better for the environment.

  • Deep cleaning

The enzymes in these cleaners work their way into even the smallest crevices. Enzymatic cleaners often provide a deeper clean than traditional cleaning products.

  • Odor removing

Enzymatic cleaners are especially effective at removing foul odors, including pet odors.

  • Long-lasting

The enzymes that enzymatic cleaners leave behind linger on surfaces. They continue to work for up to 24 hours to fully remove dirt and odors.

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For your safety
Store enzymatic cleaners in a dry location where they won’t freeze or overheat.
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Testing enzymatic cleaners
We spent 68 hours while researching 17 enzymatic cleaners. We bought our favorite and tested it on different stains and carpets.

How do you use enzymatic cleaners?

Enzymatic cleaners can be used around the house in a variety of ways.

  • Scrub your kitchen floor, bathroom floor, and countertop tile with an enzymatic cleaner instead of bleach.

  • Banish mold and mildew around sinks, tubs, and kitchen appliances by scrubbing with an enzymatic cleaner.

  • Soak clothing and other laundry with stubborn stains, such as grease or coffee, in an enzymatic cleaner as a pre-wash treatment.

  • Get rid of pet stains on carpeting, hard floors, and furniture by applying an enzymatic cleaner, letting it soak in for a day or two, and then scrubbing it off.

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Did you know?
Many enzymatic cleaners work for 12 to 24 hours, which is why they’re so effective at breaking down stains and removing odors.

What to consider when buying enzymatic cleaners

Spray bottles vs. pour bottles

Enzymatic cleaners typically come in either spray bottles or pour bottles.

Spray bottles

Spray bottles allow you to spray the enzymatic cleaner directly on the affected area. They usually range in size from 24 to 32 ounces. Spray bottles work especially well for treating pet stains and odors.

Pour bottles

With a pour bottle, you pour the enzymatic cleaner on the affected area. It’s harder to control how much is applied with a pour bottle. However, pour bottles are typically gallon-size, so they’re a good option if you use an enzymatic cleaner regularly.

"If you purchase a large pour bottle of enzymatic cleaner, you can transfer it to an old spray bottle for easier application."

Type of stain

The formulas of enzymatic cleaners are designed to treat specific stains and odors. That’s because the enzymes they contain break down specific organic materials.

  • Proteases

Enzymatic cleaners that contain proteases target protein-based stains, such as blood, urine, feces, food, and wine.

  • Amylases

Enzymatic cleaners that contain amylases target starch-based stains, such as sugars, eggs, ice cream, and sauces.

  • Lipases

Enzymatic cleaners that contain lipases target fat-based stains, such as grease and oil.

  • Multiple enzymes

Some enzymatic cleaners contain a combination of enzymes to treat a wide range of stains.

"In addition to enzymes, enzymatic cleaners also contain “good” bacteria, which breaks down the stains and odors from organic materials."


For particularly stubborn or foul-smelling stains, a concentrated enzymatic cleaner is best. Instead of the standard formula, look for a cleaner that’s designated “super strength,” “industrial strength,” or “commercial strength.” These concentrated cleaners contain more enzymes, so they work faster and more effectively than standard enzymatic cleaners.

Drying time

Enzymatic cleaners need to dry completely to effectively remove stains and odors. Some cleaners dry faster than others, so it’s important to consider the drying time for the formula you’re considering. Look for a enzymatic cleaner that dries completely in 12 to 24 hours.

"Don’t use cleaning products with a high pH on the same surface as an enzymatic cleaner. A high pH can neutralize the enzymes, so the cleaner won’t be as effective."


Many enzymatic cleaners are unscented. However, some formulas do have a scent, which can be fairly strong. If you’re sensitive to fragrances, avoid cleaners that are scented.


Enzymatic cleaners vary in price based on the size of the bottle and the concentration of the formula, but you can typically expect to spend between $10 and $50.

For a 24- to 32-ounce spray bottle of enzymatic cleaner, you’ll usually pay between $10 and $20. For a gallon pour bottle of enzymatic cleaner, you’ll usually pay between $25 and $50.

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Did you know?
Enzymatic cleaners typically have a shelf life of one to two years before they start losing their effectiveness.

Tips for using enzymatic cleaners

  • Before you apply an enzymatic cleaner to a stain, make sure the area is clean of any other chemicals, including soap or detergent. Even natural cleaners like vinegar should be rinsed away because they may inhibit the effectiveness of the enzymes.

  • Most enzymatic cleaners should be used at full strength. Check the label before diluting any cleaner with water.

  • Avoid damage to the surfaces you’re cleaning by testing the enzymatic cleaner in an inconspicuous spot. Once you’re sure that it doesn’t remove any color from the surface, you can use the cleaner all over.

  • After you’ve applied an enzymatic cleaner, cover the affected area with a piece of plastic to create a warm, humid environment to boost the enzyme action.

  • Some enzymatic cleaners aren’t suitable for use on hardwood floors or other surfaces, so be sure to read the label carefully to check where you can use the cleaner.

  • For particularly stubborn stains, scrub the enzymatic cleaner into the affected area with a soft bristle brush for a minute or two before allowing it to dry.

  • The enzymes in enzymatic cleaners don’t hold up well to extreme temperatures, so you shouldn’t use them with hot water.

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Enzymatic cleaners can be used outdoors to clean patio surfaces. With these cleaners, no toxic chemicals will affect your grass, plants, and shrubs.


Q. Are enzymatic cleaners safe to use around children and pets?

A. Enzymatic cleaners don’t contain toxic ingredients, so they’re much safer than traditional cleaning products. You can use them safely around children and pets. However, as with any cleaning product, make sure that enzymatic cleaners are kept in a secure location where children and pets can’t access them.

Q. What types of stains do enzymatic cleaners remove?

A. Enzymatic cleaners work well on a variety of organic stains. They can break down blood, urine, and other bodily fluids to remove the associated stains and odors, but they’re also effective at removing food stains, including oil, grease, and wine.

Q. Can I use an enzymatic cleaner in a carpet cleaner or steamer?

A. Enzymatic cleaners should not be used in carpet cleaners or steamers. These appliances use extremely high temperatures to heat water and convert it to steam, which can prevent the enzymes from working effectively.

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